Hemorrhage caused by snake venom metalloproteinases: a journey of discovery and understanding

JM Gutiérrez, T Escalante, A Rucavado, C Herrera - Toxins, 2016 - mdpi.com
The historical development of discoveries and conceptual frames for understanding the
hemorrhagic activity induced by viperid snake venoms and by hemorrhagic …

[HTML][HTML] Snake venom metalloproteinases (SVMPs): a structure-function update

OT Olaoba, PK Dos Santos, HS Selistre-de-Araujo… - Toxicon: X, 2020 - Elsevier
Snake venom metalloproteinases (SVMPs) represent a diverse group of multi-domain
proteins with several biological activities such as the ability to induce hemorrhage …

Metalloproteases affecting blood coagulation, fibrinolysis and platelet aggregation from snake venoms: Definition and nomenclature of interaction sites

RM Kini, CY Koh - Toxins, 2016 - mdpi.com
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey,
affect various physiological functions by cleaving specific proteins. They exhibit their …

Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases

T Escalante, A Rucavado, JW Fox, JM Gutiérrez - Journal of proteomics, 2011 - Elsevier
Hemorrhage is one of the most significant effects in envenomings induced by viperid
snakebites. Damage to the microvasculature, induced by snake venom metalloproteinases …

Haemostatically active proteins in snake venoms

T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): Novel perspectives on the …

JM Gutiérrez, T Escalante, A Rucavado, C Herrera… - Toxins, 2016 - mdpi.com
Snake venom metalloproteinases (SVMPs) affect the extracellular matrix (ECM) in multiple
and complex ways. Previously, the combination of various methodological platforms …

[HTML][HTML] Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII …

LA Freitas-de-Sousa, DR Amazonas, LF Sousa… - Biochimie, 2015 - Elsevier
Comparisons between venoms from snakes kept under captivity or collected at the natural
environment are of fundamental importance in order to obtain effective antivenoms to treat …

Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases

T Escalante, N Ortiz, A Rucavado, EF Sanchez… - PloS one, 2011 - journals.plos.org
Hemorrhage is a clinically important manifestation of viperid snakebite envenomings, and is
induced by snake venom metalloproteinases (SVMPs). Hemorrhagic and non-hemorrhagic …

Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application

MI Estevão-Costa, R Sanz-Soler… - The international journal …, 2018 - Elsevier
Both mythologically and logically, snakes have always fascinated man. Snakes have
attracted both awe and fear not only because of the elegant movement of their limbless …

Snake venom disintegrins and cell migration

HS Selistre-de-Araujo, CLS Pontes, CF Montenegro… - Toxins, 2010 - mdpi.com
Cell migration is a key process for the defense of pluricellular organisms against pathogens,
and it involves a set of surface receptors acting in an ordered fashion to contribute …