The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

In multicellular organisms, development is based in part on the integration of communication
systems. Two neuroendocrine axes, the hypothalamic–pituitary–thyroid and the …

The environment experienced by developing organisms can shape the timing and character
of developmental processes, generating different phenotypes from the same genotype, each …

We gathered available RNA-seq and ChIP-seq data in a single database to better
characterize the target genes of thyroid hormone receptors in several cell types. This …

Thyroid hormone (TH) is the most important hormone in frog metamorphosis, a
developmental process which will not occur in the absence of TH but can be induced …

Glucocorticoids, vertebrate steroid hormones produced by cells of the adrenal cortex or
interrenal tissue, function dynamically to maintain homeostasis under constantly changing …

Observations on the ontogeny and diversity of salamanders provided some of the earliest
evidence that shifts in developmental trajectories have made a substantial contribution to the …

Thyroid hormone (TH) is required for frog metamorphosis, and corticosterone (CORT)
increases TH signaling to accelerate metamorphic progression. However, a requirement for …

Krüppel-like factors (KLFs) are zinc finger transcription factors implicated in diverse
biological processes, including differentiation of neural cells. The ability of mammalian …

Thyroid hormones exert a broad influence on brain development and function, which has
been extensively studied over the years. Mouse genetics has brought an important …