Transmembrane (TM) proteins are major drug targets, but their structure determination, a
prerequisite for rational drug design, remains challenging. Recently, the DeepMind's …

Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …

ATP‐binding cassette (ABC) transporters are fascinating molecular machines that are
capable of transporting a large variety of chemically diverse compounds. The energy …

Protein misfolding is involved in a large number of diseases, among which cystic fibrosis.
Complex intra-and inter-domain folding defects associated with mutations in the cystic …

The number of unique transmembrane (TM) protein structures doubled in the last four years,
which can be attributed to the revolution of cryo-electron microscopy. In addition, AlphaFold2 …

Cystic fibrosis (CF) is a rare genetic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR), an epithelial anion channel expressed in …

CFTR is an anion channel that has evolved from the mold of an ABC transporter. It
possesses specific structural features, including a lateral portal between the cytoplasmic …

Cystic fibrosis, the most common autosomal recessive disorder in Caucasians, is caused by
mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which …

The recent elucidation of atomistic structures of Cl− channel CFTR provides opportunities for
understanding the molecular basis of cystic fibrosis. Despite having been activated through …

The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in
cellular transport mechanisms, influencing a wide range of physiological processes and …