Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

A renewed interest in the characteristics and neural basis of corneal and conjunctival
sensations is developing in recent years due to the high incidence of discomfort and altered …

Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

PURPOSE: The corneal innervation, mainly analyzed in light microscopical studies, has
been described as radially oriented stromal nerve bundles that ramify as leashes in the …

PURPOSE: Although the human cornea is densely innervated, observations of the nerve
fiber distribution and ultrastructure are scarce. This study aimed to provide a detailed …

Sensory information that arises in orofacial organs facilitates exploratory, ingestive, and
defensive behaviors that are essential to overall fitness and survival. Because the …