Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury
to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm …

Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated
with poor clinical outcomes. Although the importance and impact of lung-protective …

Patients with severe lung injury usually have a high respiratory drive, resulting in intense
inspiratory effort that may even worsen lung damage by several mechanisms gathered …

Rationale: Monitoring and controlling respiratory drive and effort may help to minimize lung
and diaphragm injury. Airway occlusion pressure (P0. 1) is a noninvasive measure of …

Methods We conducted a retrospective, bicenter study at the Sainte Anne Military Hospital
and the Marseille University North Hospital. This study enrolled critically ill patients with mild …

Background: Monitoring and controlling lung stress and diaphragm effort has been
hypothesized to limit lung injury and diaphragm injury. The occluded inspiratory airway …

During assisted mechanical ventilation, spontaneous inspiratory effort can cause both lung
(patient self-inflicted lung injury [P-SILI]) and diaphragm injury. While clinicians are primarily …

There is a well-recognised importance for personalising mechanical ventilation settings to
protect the lungs and the diaphragm for each individual patient. Measurement of …

Background There is very limited evidence identifying factors that increase respiratory drive
in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot …