Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

In past decades, interdisciplinary research has been of great interest for scholars.
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …

Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Besides fast glucose catabolism, many types of cancers are characterized by elevated
glutamine consumption. Medical oncology pursuits to block specific pathways, mainly …

Enzymes are common targets in high-throughput screening and related campaigns. An
analysis of papers published between 1990 and 2018 showed that kinases were the most …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

It has been demonstrated that glutamine metabolism has become the main energy and
building blocks supply for the growth and viability of a potentially large subset of malignant …

Glutaminase (GLS), which is responsible for the conversion of glutamine to glutamate, plays
a vital role in up-regulating cell metabolism for tumor cell growth and is considered to be a …

Abstract Glutaminase-1 (GLS1) is a critical enzyme involved in several cellular processes,
and its overexpression has been linked to the development and progression of cancer …

Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of
metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine …