Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution

Q Zeng, B Bie, Q Guo, Y Yuan, Q Han… - Proceedings of the …, 2020 - National Acad Sciences
We report hyperpolarized Xe signal advancement by metal-organic framework (MOF)
entrapment (Hyper-SAME) in aqueous solution. The 129Xe NMR signal is drastically …

Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

V Alterio, A Di Fiore, K D'Ambrosio, CT Supuran… - Chemical …, 2012 - ACS Publications
Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

A review of responsive MRI contrast agents: 2005–2014

DV Hingorani, AS Bernstein… - Contrast media & …, 2015 - Wiley Online Library
This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

R Kubota, I Hamachi - Chemical Society Reviews, 2015 - pubs.rsc.org
Chemical sensing of amino acids, peptides, and proteins provides fruitful information to
understand their biological functions, as well as to develop the medical and technological …

Subcellular delivery of hydrogen sulfide using small molecule donors impacts organelle stress

AK Gilbert, MD Pluth - Journal of the American Chemical Society, 2022 - ACS Publications
Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with
important roles in regulating organelle function and stress. Because of its high reactivity …

Xenon for NMR biosensing–inert but alert

L Schröder - Physica Medica, 2013 - Elsevier
NMR studies with hyperpolarized xenon as functionalized sensor or contrast agent recently
made notable progress in developing a new approach for detecting molecular markers and …

Opportunities and challenges with hyperpolarized bioresponsive probes for functional imaging using magnetic resonance

G Angelovski, BJ Tickner, G Wang - Nature Chemistry, 2023 - nature.com
The development of hyperpolarized bioresponsive probes for magnetic resonance imaging
(MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of …