The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

Interest in the field of epigenetics has increased rapidly over the last decade, with the term
becoming more identifiable in biomedical research, scientific fields outside of the molecular …

Every nucleosome across the genome must be disrupted and reformed when the replication
fork passes, but how chromatin organization is re-established following replication is …

The compact structure of the nucleosome limits DNA accessibility and inhibits the binding of
most sequence-specific proteins. Nucleosomes are not randomly located on the DNA but …

Genomic integrity is crucial for correct chromosome segregation and physiological rates of
cell proliferation. Mutations, deletions and translocations, hallmarks of human tumors, drive …

Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved
hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) …

Core histone acetylation is a key prerequisite for chromatin decondensation and plays a
pivotal role in regulation of chromatin structure, function and dynamics. The addition of …

Chromatin modifications have been well-established to play a critical role in the regulation of
genome function. Many of these modifications are introduced and removed by enzymes that …

The DNA replication program is, in part, determined by the epigenetic landscape that
governs local chromosome architecture and directs chromosome duplication. Replication …