Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …

Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …

Recent studies have deepened our understanding of multiple mechanisms by which
extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …

Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and
hair removal, similar to behavior in humans with the obsessive-compulsive disorder …

Several psychiatric disorders—such as bipolar disorder, schizophrenia and autism—are
highly heritable, yet identifying their genetic basis has been challenging, with most …

Abstract Objective Vitamins B6 and B12 are involved in metabolic processes that decrease
neural excitation and increase inhibition. This double‐blind study investigated the effects of …

Hoxb8 mutant mice show compulsive behavior similar to trichotillomania, a human
obsessive-compulsive-spectrum disorder. The only Hoxb8 lineage-labeled cells in the …

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical
use. Remarkably, the effector molecules through which these medications exert their actions …