Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

α-Lactalbumin (α-LA) is a small (Mr 14,200), acidic (pI 4–5), Ca2+-binding protein. α-LA is a
regulatory component of lactose synthase enzyme system functioning in the lactating …

Milk represents a unique resource for translational medicine: It contains a rich pool of
biologically active molecules with demonstrated clinical benefits. The ongoing …

A complex formed by human α-lactalbumin (α-LA) and oleic acid (OA), named HAMLET, has
been shown to have an apoptotic activity leading to the selective death of tumor cells. In …

Lipid–protein complexes comprised of oleic acid (OA) non-covalently coupled to
human/bovine α-lactalbumin, named HAMLET/BAMLET, display cytotoxic properties against …

Background: Oleic Acid (OA) has been shown to have anticancer properties mediated by
interaction with proteins such as α-lactalbumin and lactoferrins. Therefore, we synthesized …

A chance discovery of the tumoricidal action of a human milk fraction led to the
characterization of the active component as oleic acid complex of the α-lactalbumin, which …

HAMLET (human alpha-lactalbumin made lethal to t umor cells) interacts with multiple tumor
cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin …

Targeted drug delivery into the cell compartment that is the most vulnerable to effects of the
corresponding drug is a challenging problem, and its successful solution can significantly …

To better understand the formation mechanism of apo-α-lactalbumin (α-LA)/Oleic acid (OA)
complexes, this research used fluorescence spectroscopy and circular dichroism …