Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …

The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory
consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity …

The sequences and structures of 3′-untranslated regions (3′ UTRs) of messenger RNAs
govern their stability, localization, and expression. 3′ UTR regulatory elements are …

RNA–protein interactions are essential for proper gene expression regulation, particularly in
neurons with unique spatial constraints. Currently, these interactions are defined …

Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert
robust effects on neuronal survival, synapse stabilization, and synaptic function. Key …

Abstract mRNA transport in neurons requires formation of transport granules containing
many protein components, and subsequent alterations in phosphorylation status can …

Spatiotemporal control of gene expression is important for neural development and function.
Here, we show that heterogeneous nuclear ribonucleoprotein (hnRNP) A/B is highly …

A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated
protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions …

Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse
types of experience-dependent synaptic plasticity and long-term memory in mammals …