The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …

The processes of mRNA export from the nucleus and subsequent mRNA translation in the
cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as …

Objective Determining the genetic basis of speech disorders provides insight into the
neurobiology of human communication. Despite intensive investigation over the past 2 …

Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …

Immune checkpoint blockade (ICB) has revolutionized cancer therapy. However, the
response of patients to ICB is difficult to predict. Here, we examined 81 patients with lung …

Severe speech disorders lead to poor literacy, reduced academic attainment and negative
psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was …

Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating
mRNAs carrying a premature termination codon and a pathway that regulates many genes …

Expansion of an intronic (GGGGCC) n repeat region within the C9orf72 gene is a main
cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). A …

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover
pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential …