Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Hereditary cancers derive from gene defects that often compromise DNA repair. Thus, BRCA-
associated cancers are sensitive to DNA-damaging agents such as cisplatin. The efficacy of …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Replicative polymerases (pols) cannot accommodate damaged template bases, and these
pols stall when such offenses are encountered during S phase. Rather than repairing the …

Summary Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the
integrated stress response (ISR) that enables cell survival under nutrient stress. The …

The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB
proteins have emerged as critical factors that regulate the lineage commitment …

Defects in DNA replication, DNA damage response, and DNA repair compromise genomic
stability and promote cancer development. In particular, unrepaired DNA lesions can arrest …

DNA damage tolerance pathways, which include translesion DNA synthesis (TLS) and
template switching, are crucial for prevention of DNA replication arrest and maintenance of …