Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis
Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
Advanced evanescent-wave optical biosensors for the detection of nucleic acids: An analytic perspective
Evanescent-wave optical biosensors have become an attractive alternative for the screening
of nucleic acids in the clinical context. They possess highly sensitive transducers able to …
of nucleic acids in the clinical context. They possess highly sensitive transducers able to …
Exosite binding in thrombin: a global structural/dynamic overview of complexes with aptamers and other ligands
Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …
Mechanism and thermodynamics of adsorption of diclofenac on graphene-based nanomaterials
The widely used anti-inflammatory diclofenac (DCF) is one of the pharmaceutical drugs most
frequently detected in the environment as it is not fully degraded by conventional water …
frequently detected in the environment as it is not fully degraded by conventional water …
[HTML][HTML] Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy
Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have
shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early …
shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early …
One-step immobilization of antibodies and DNA on gold sensor surfaces via a poly-adenine oligonucleotide approach
Label-free plasmonic biosensors have demonstrated promising capabilities as analytical
tools for the detection of virtually any type of biomarker. They are presented as good …
tools for the detection of virtually any type of biomarker. They are presented as good …
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
R Troisi, C Riccardi, KP de Carvasal… - … Therapy-Nucleic Acids, 2022 - cell.com
Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks
that continue to hinder their applications. Several strategies have been undertaken to …
that continue to hinder their applications. Several strategies have been undertaken to …
Integration of functional peptides into nucleic acid-based nanostructures
JS Freitag, C Möser, R Belay, B Altattan, N Grasse… - Nanoscale, 2023 - pubs.rsc.org
In many applications such as diagnostics and therapy development, small peptide fragments
consisting of only a few amino acids are often attractive alternatives to bulky proteins. This is …
consisting of only a few amino acids are often attractive alternatives to bulky proteins. This is …
Chemical modifications in nucleic acids for therapeutic and diagnostic applications
The last decade has witnessed the blooming of nucleic acids for therapeutic and diagnostic
applications. In the present article, we describe the most important results from our group in …
applications. In the present article, we describe the most important results from our group in …
Fast and accurate pneumocystis pneumonia diagnosis in human samples using a label-free plasmonic biosensor
Pneumocystis jirovecii is a fungus responsible for human Pneumocystis pneumonia, one of
the most severe infections encountered in immunodepressed individuals. The diagnosis of …
the most severe infections encountered in immunodepressed individuals. The diagnosis of …