The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives

L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Mucosal vaccines: the promise and the challenge

MR Neutra, PA Kozlowski - Nature reviews immunology, 2006 - nature.com
Most infectious agents enter the body at mucosal surfaces and therefore mucosal immune
responses function as a first line of defence. Protective mucosal immune responses are most …

Nutritional and technological aspects of milk fat globule membrane material

K Dewettinck, R Rombaut, N Thienpont, TT Le… - International dairy …, 2008 - Elsevier
The milk fat globule membrane (MFGM) has gained a lot of attention recently, due to the
growing interest in its nutritional and technological properties. The whole membrane as well …

[HTML][HTML] Sphingolipids in food and the emerging importance of sphingolipids to nutrition

H Vesper, EM Schmelz, MN Nikolova-Karakashian… - The Journal of …, 1999 - Elsevier
Eukaryotic organisms as well as some prokaryotes and viruses contain sphingolipids, which
are defined by a common structural feature, ie, a “sphingoid base” backbone such as D …

Virus entry, assembly, budding, and membrane rafts

N Chazal, D Gerlier - Microbiology and molecular biology reviews, 2003 - Am Soc Microbiol
As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries
for completion of their replication cycle. The recent discovery of the heterogeneous …

Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.

AH Merrill Jr, MC Sullards, E Wang… - Environmental health …, 2001 - ehp.niehs.nih.gov
Sphingolipids have important roles in membrane and lipoprotein structure and in cell
regulation as second messengers for growth factors, differentiation factors, cytokines, and a …

[HTML][HTML] Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4

L Espert, M Denizot, M Grimaldi… - The Journal of …, 2006 - Am Soc Clin Investig
HIV-1 envelope glycoproteins (Env), expressed at the cell surface, induce apoptosis of
uninfected CD4+ T cells, contributing to the development of AIDS. Here we demonstrate that …

Milk fat in human nutrition

PW Parodi - Australian Journal of Dairy Technology, 2004 - search.proquest.com
Abstract Ravnskov (1998) presented data for 28 cohorts from 21 prospective studies. In only
3 of these cohorts was saturated fat intake associated with an increased risk of CHD. CHD …

Beyond RGD: virus interactions with integrins

HAM Hussein, LR Walker, UM Abdel-Raouf… - Archives of …, 2015 - Springer
Viruses successfully infect host cells by initially binding to the surfaces of the cells, followed
by an intricate entry process. As multifunctional heterodimeric cell-surface receptor …

A novel carbohydrate-glycosphingolipid interaction between a β-(1–3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes

JW Zimmerman, J Lindermuth, PA Fish… - Journal of Biological …, 1998 - ASBMB
The immunomodulator Betafectin® PGG-glucan is a homopolymer of glucose derived from
yeast cell walls which has been demonstrated to enhance leukocyte anti-infective activity in …