The concept of activation in the absence of agonists has been demonstrated for many
GPCRs and is now solidified as one of the principal aspects of GPCR signaling. In this …

Photorhabdus luminescens is an insect pathogenic bacterium that is symbiotic with
entomopathogenic nematodes. On invasion of insect larvae, P. luminescens is released …

Single pass cell surface receptors regulate cellular processes by transmitting ligand-
encoded signals across the plasma membrane via changes to their extracellular and …

Abstract Background The CWxP motif of transmembrane helix 6 (x: any residue) is highly
conserved in class A GPCRs. Within this motif, W6. 48 is a big star in the theory of the global …

Purpose.: In experimental eye research, zebrafish has become a powerful model for human
retina disorders. The purpose of the present study is the characterization of antibodies …

The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis and has
emerged as a premier target for obesity treatment. Numerous mutations in transmembrane …

Abstract The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis
and has emerged as a premier target for obesity treatment. Numerous mutations in …

The present work reports a 0.1 μs molecular dynamics simulation of a bovine rhodopsin
dimer based on a recently reported semi-empirical model obtained by fitting two monomers …

This study represents the first attempt to couple, by computational experiments, the
mechanisms of intramolecular and intermolecular communication concerning a guanidine …

Rod cell membranes contain cholesterol-rich detergent-resistant membrane (DRM) rafts,
which accumulate visual cascade proteins as well as proteins involved in regulation of …