The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

The life and times of a tRNA

EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

[HTML][HTML] The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult

B Zhang, G Arun, YS Mao, Z Lazar, G Hung… - Cell reports, 2012 - cell.com
Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …

A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly (A) tails

JE Wilusz, CK JnBaptiste, LY Lu, CD Kuhn… - Genes & …, 2012 - genesdev.cshlp.org
The MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is
misregulated in many human cancers and produces an abundant long nuclear-retained …

[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms

A Łabno, R Tomecki, A Dziembowski - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

RNA Degradation in Saccharomyces cerevisae

R Parker - Genetics, 2012 - academic.oup.com
All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

[HTML][HTML] tRNA renovatio: rebirth through fragmentation

B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

JE Wilusz - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
Most of the human genome is transcribed, yielding a complex network of transcripts that
includes tens of thousands of long noncoding RNAs. Many of these transcripts have a 5 …

Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications

T Chujo, K Tomizawa - The FEBS journal, 2021 - Wiley Online Library
tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …