Atherosclerosis is commonly known as an inflammatory disease that is characterized by lipid
deposition in the arterial wall, causing gradual restriction or complete blockade of blood …

Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular
function and homeostasis. They regulate vascular tone, oxidative stress, and permeability …

Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the
development of atherosclerosis. However, the molecular basis for the regulation of …

BACKGROUND: Despite endothelial dysfunction being an initial step in the development of
hypertension and associated cardiovascular/renal injuries, effective therapeutic strategies to …

The physiology of lipid droplets (LDs) has been most extensively characterized in
adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to …

Apolipoprotein B (apoB) is the main structural protein of LDLs, triglyceride-rich lipoproteins
and lipoprotein (a), and is crucial for their formation, metabolism and atherogenic properties …

Since the discovery of statins and the Scandinavian Simvastatin Survival Study (4S) results
three decades ago, remarkable advances have been made in the treatment of …

Atherosclerosis begins with the infiltration of cholesterol-containing lipoproteins into the
arterial wall. White blood cell (WBC)-associated inflammation follows. Despite decades of …

Obesity is a multifactorial metabolic disorder associated with endothelial dysfunction and
increased risk of cardiovascular disease. Adipose capillary adipose endothelial cells …

Cerebrovascular injuries leading to edema and hemorrhage after ischemic stroke are
common. The mechanisms underlying these events and how they are connected to known …