Transition metal catalysis has dramatically changed the face of modern organic chemistry by
introducing a range of novel synthetic methods. A number of outstanding catalytic systems …

Coupling reactions form an important class of reactions in organic synthesis and these
reactions are usually catalysed by metals and are of great significance. Copper due to its …

2 H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions
of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the …

Starting from a screening-hit compound, via structure modifications and optimizations, a
series of nonfused and nonassembly pyrimidinylthiourea derivatives (2–5) was designed …

Aryl amines are synthesized from halobenzenes via copper mediated reactions employing
sodium azide under mild conditions in ethanol/water. The reaction proceeds stepwise via …

To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors
containing the 2, 3-diaminopyridine moiety were designed and synthesized. The amide …

The amination of aryl halides in liquid ammonia (LNH3) is catalyzed by a copper (I)
salt/ascorbate system to yield primary aromatic amines in good to excellent yields. The low …

A strategic approach towards the synthesis of 6-amino-2-naphthol for energy efficient and
consistent yield was exploited by two protocols:(a) a direct amination, and (b) a cascade …

A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the
synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated …

Considering the importance of PDE4D inhibition and the modulation of biometals in
Alzheimer's disease (AD) therapeutics, we have designed, synthesized and evaluated a …