Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

[HTML][HTML] Cross-linked hydrogel for pharmaceutical applications: a review

R Parhi - Advanced pharmaceutical bulletin, 2017 - ncbi.nlm.nih.gov
Hydrogels are promising biomaterials because of their important qualities such as
biocompatibility, biodegradability, hydrophilicity and non-toxicity. These qualities make …

Stimulus-responsive hydrogels: Theory, modern advances, and applications

MC Koetting, JT Peters, SD Steichen… - Materials Science and …, 2015 - Elsevier
Over the past century, hydrogels have emerged as effective materials for an immense variety
of applications. The unique network structure of hydrogels enables very high levels of …

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Y Adachi, K Ueda, S Nomura, K Ito, M Katoh… - Nature …, 2022 - nature.com
Although inflammation plays critical roles in the development of atherosclerosis, its
regulatory mechanisms remain incompletely understood. Perivascular adipose tissue …

Mucosal applications of poloxamer 407-based hydrogels: An overview

E Giuliano, D Paolino, M Fresta, D Cosco - Pharmaceutics, 2018 - mdpi.com
Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …

Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy

Y Xiao, Y Gu, L Qin, L Chen, X Chen, W Cui, F Li… - Colloids and Surfaces B …, 2021 - Elsevier
Injectable thermosensitive hydrogel has been regarded as attractive drug delivery system,
which displays a sol-gel phase transition upon injection in response to temperature …

Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

C Englert, JC Brendel, TC Majdanski, T Yildirim… - Progress in Polymer …, 2018 - Elsevier
The administration of drugs, as a main challenge of pharmaceutical and medicinal
applications, has certainly benefited from the application of synthetic polymers. However …

[HTML][HTML] Research progress of in-situ gelling ophthalmic drug delivery system

Y Wu, Y Liu, X Li, D Kebebe, B Zhang, J Ren… - Asian journal of …, 2019 - Elsevier
Blindness and vision impairment are the most devastating global health problems resulting
in a substantial economic and social burden. Delivery of drug to particular parts of the …

Chitosan and carboxymethyl cellulose-based 3D multifunctional bioactive hydrogels loaded with nano-curcumin for synergistic diabetic wound repair

SA Shah, M Sohail, M Karperien, C Johnbosco… - International journal of …, 2023 - Elsevier
Biopolymer-based thermoresponsive injectable hydrogels with multifunctional tunable
characteristics containing anti-oxidative, biocompatibility, anti-infection, tissue regeneration …

Recent progress in biomedical applications of Pluronic (PF127): Pharmaceutical perspectives

MSH Akash, K Rehman - Journal of Controlled Release, 2015 - Elsevier
Most of the administered anti-cancer drugs are hydrophobic in nature and are known to
have poor water solubility, short residence time, rapid clearance from the body and systemic …