How cancer hijacks the body's homeostasis through the neuroendocrine system

RM Slominski, C Raman, JY Chen, AT Slominski - Trends in neurosciences, 2023 - cell.com
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

BS Katzenellenbogen, VS Guillen… - Breast Cancer …, 2023 - Springer
Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

FOXM1: A small fox that makes more tracks for cancer progression and metastasis

MA Khan, P Khan, A Ahmad, M Fatima… - Seminars in Cancer …, 2023 - Elsevier
Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

Small-molecule inhibitors targeting FOXM1: current challenges and future perspectives in cancer treatments

S Raghuwanshi, AL Gartel - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …

Preparation of a novel hyaluronic acid-based separable hydrogel microneedle with niacinamide to treat pigment deposition using solvent-free solid-state crosslinking …

J Lv, J Zhao, X Li, G Ling, P Zhang - European Polymer Journal, 2024 - Elsevier
With the increase in age and prolonged exposure to ultraviolet radiation, especially on the
face, pigment deposition often has a negative impact on individuals physically and …

NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells

C Liu, M Vorderbruggen, C Muñoz-Trujillo… - Journal of Ovarian …, 2024 - Springer
Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a
potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated …

Examination of the roles of CgTH in tyrosine metabolism and pigmentation of Pacific oyster (Crassostrea gigas)

K Jiang, H Yu, L Kong, S Liu, S Du, Q Li - Aquaculture, 2025 - Elsevier
The visually appealing shell colours and intricate patterns of shellfish not only attract
consumers but also enhance their economic value. Understanding the inheritance pattern of …

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression

J Kohli, C Ge, E Fitsiou, M Doepner… - Nature …, 2022 - nature.com
Human melanocytic nevi (moles) result from a brief period of clonal expansion of
melanocytes. As a cellular defensive mechanism against oncogene-induced hyperplasia …

Association between glycemic traits and melanoma: a mendelian randomization analysis

YC Zhang, CD Lu, QY Li, JN Shi, J Shi, M Yang - Frontiers in Genetics, 2023 - frontiersin.org
Background: The causation of Glycemic Traits and risks of Melanoma remains unknown. We
used Mendelian Randomization (MR) to assess the links between Glycemic Traits and …

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

S Huang, P Kuri, J Zou, A Blanco, M Marshall, G Rice… - bioRxiv, 2022 - biorxiv.org
The skin has a pronounced ability to adapt to physical changes in the environment by
exhibiting plasticity at the cellular level. Transient mechanical deformations applied to the …