RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

The impressive clinical activity of small-molecule receptor tyrosine kinase inhibitors for
oncogene-addicted subgroups of non-small-cell lung cancer (for example, those driven by …

Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers,
early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this …

Hotspot mutations in splicing factor genes have been recently reported at high frequency in
hematological malignancies, suggesting the importance of RNA splicing in cancer. We …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

In lung adenocarcinoma, oncogenic EGFR mutations co-occur with many tumor suppressor
gene alterations; however, the extent to which these contribute to tumor growth and …

Cancer is thought to arise through the accumulation of genomic aberrations evolving under
Darwinian selection. However, it remains unclear when the aberrations associated with …

RNA splicing is an essential process that governs many aspects of cellular proliferation,
survival, and differentiation. Considering the importance of RNA splicing in gene regulation …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …