Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …

Cyclin-dependent kinase 9 (CDK9), which regulates transcriptional elongation, is an
attractive therapeutic target for many cancers, especially for cancers driven by transcriptional …

Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …

Protein kinases have been important targets for antitumor targets due to their key roles in
regulating multiple cell signaling pathways. Numerous compounds containing flavonoid …

Kinases have gained an important place in the list of vital therapeutic targets because of
their overwhelming clinical success in the last two decades. Among various clinically …

Rohitukine, a chromone alkaloid extracted from Dysoxylum binectariferum, has a propitious
anticancer activity. Our previous study shows that a new Rohitukine derivative IIIM‐290 …

Cancer is one of the major leading causes of death worldwide despite many breakthroughs
in the development of novel anticancer drugs. The heterodimer CDK-Cyclin complex plays …

Specific inhibition of CDK9 is considered a promising strategy for developing effective
anticancer therapeutics. However, most of the reported CDK9 inhibitors are still at an early …

Abstract The styryl (Ph‐CH= CH‐R) group is widely represented in medicinally important
compounds, including drugs, clinical candidates, and molecular probes as it positively …

Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …