Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Transient receptor potential (TRP) channels are recently identified proteins that form a
versatile family of ion channels, the majority of which are calcium permeable and exhibit …

TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal
neurons that are related to pathophysiology in migraine models. Here we use a mouse …

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-
temperature-sensing organs, and is regulated by downstream receptor–activated signaling …

Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary
somatosensory neurons termed nociceptors. The molecular receptors of noxious …