Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the …

Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …

The Notch signaling pathway is a critical player in embryogenesis but also plays various
roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations …

Mechanical cues influence tissue regeneration, and although vasculature is known to be
mechanically sensitive, little is known about the effects of bulk extracellular matrix …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Cell signalling and mechanics influence vascular pathophysiology and there is an
increasing demand for in vitro model systems that enable examination of signalling between …

Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …

Biophysical and biochemical cues work in concert to regulate angiogenesis. These cues
guide angiogenesis during development and wound healing. Abnormal cues contribute to …