We are on the brink of harnessing the cell's natural defenses against ischemia and
reperfusion injury after years of research into the destructive and protective mechanisms …

BACKGROUND: In addition to its anti-ischaemic effects, the antianginal drug nicorandil is
thought to have cardioprotective properties. We did a randomised trial to find out whether …

Background—Myocyte necrosis as a result of elective percutaneous coronary intervention
(PCI) occurs in approximately one third of cases and is associated with subsequent …

1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …

Background—Intravenous nicorandil, a hybrid compound of ATP-sensitive potassium
channel opener and nitric oxide donor, has been reported to ameliorate early functional and …

The phenomenon of “ischemic preconditioning” has been recognized for almost two
decades. In experimental animals and humans, a brief period of ischemia has been shown …

Diabetic patients are more prone to develop postinfarction complications. It remained
unclear whether diabetes mellitus-or sulfonylureas-associated changes of ATP-sensitive …

Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension,
diabetes, and smoking. These conditions are associated with endothelial dysfunction, which …

Nitrates have been used to treat symptoms of chronic stable angina for over 135 years.
These drugs are known to activate nitric oxide (NO)-cyclic guanosine-3′,-5 …

Nicorandil is a drug with both nitrate-like and ATP-sensitive potassium-channel (K+ ATP)
activating properties. By virtue of this dual mechanism of action, the drug acts as a balanced …