Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited
treatment options. CD47 is a cell-surface molecule that promotes immune evasion by …

Antibodies targeting PD-1 have been demonstrated durable anti-cancer activity in certain
cancer types. However, the anti-PD-1 antibodies are less or not efficacious in many …

Daratumumab (DARA) is a human CD38-specific IgG1 antibody that is in clinical
development for the treatment of multiple myeloma (MM). The potential for IgG1 antibodies …

Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …

Macrophages enforce antitumor immunity by engulfing and killing tumor cells. Although
these functions are determined by a balance of stimulatory and inhibitory signals, the role of …