The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

Multiple myeloma (MM) remains incurable despite advances in current treatment. Patients
with MM exhibit significant variations in their prognosis and survival. Recently, genetic …

RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …

A diversity of gene regulatory mechanisms drives the changes in gene expression required
for animal development. Here, we discuss the developmental roles of a class of gene …

RNA interference (RNAi) is a conserved gene silencing process that exists in diverse
organisms to protect genome integrity and regulate gene expression. In C. elegans, the …

Small RNA pathways defend the germlines of animals against selfish genetic elements, yet
pathway activities need to be contained to prevent silencing of self genes. Here, we reveal a …

Genetic mechanisms that repress transposable elements (TEs) in young animals decline
during aging, as reflected by increased TE expression in aged animals. Does increased TE …

The objective of this chapter is to provide an overview of the chemical and mechanistic
classes of oligonucleotide-based therapeutics (ONTs), to describe the general strategies …

The centrosome is the microtubule-organizing center and a crucial part of cell division.
Centrosomal RNAs (cnRNAs) have been reported to enable precise spatiotemporal control …