Excessive intake of sugar: An accomplice of inflammation

X Ma, F Nan, H Liang, P Shu, X Fan, X Song… - Frontiers in …, 2022 - frontiersin.org
High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

T Jensen, MF Abdelmalek, S Sullivan, KJ Nadeau… - Journal of …, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically …

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

ME Rinella, BA Neuschwander-Tetri, MS Siddiqui… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …

The small intestine converts dietary fructose into glucose and organic acids

C Jang, S Hui, W Lu, AJ Cowan, RJ Morscher, G Lee… - Cell metabolism, 2018 - cell.com
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical
feature of sweets is fructose. Despite strong ties between fructose and disease, the …

The role of the gut microbiota in NAFLD

C Leung, L Rivera, JB Furness… - … reviews Gastroenterology & …, 2016 - nature.com
NAFLD is now the most common cause of liver disease in Western countries. This Review
explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut …

Prebiotic inulin and sodium butyrate attenuate obesity-induced intestinal barrier dysfunction by induction of antimicrobial peptides

J Beisner, L Filipe Rosa, V Kaden-Volynets… - Frontiers in …, 2021 - frontiersin.org
Defects in the mucosal barrier have been associated with metabolic diseases such as
obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) …

Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease

S Softic, DE Cohen, CR Kahn - Digestive diseases and sciences, 2016 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …

Animal models of nonalcoholic fatty liver disease—a starter's guide

MA Van Herck, L Vonghia, SM Francque - Nutrients, 2017 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the
increasing incidence of obesity and diabetes in many Western countries, reaching a …

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

S Softic, MK Gupta, GX Wang… - The Journal of …, 2017 - Am Soc Clin Investig
Overconsumption of high-fat diet (HFD) and sugar-sweetened beverages are risk factors for
developing obesity, insulin resistance, and fatty liver disease. Here we have dissected …

Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis

X Wang, ZE Zheng, JM Caviglia, KE Corey, TM Herfel… - Cell metabolism, 2016 - cell.com
Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide.
However, the molecular basis of how benign steatosis progresses to NASH is incompletely …