Menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the American Heart Association
SR El Khoudary, B Aggarwal, TM Beckie, HN Hodis… - Circulation, 2020 - Am Heart Assoc
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable
increase in the risk for this disease after menopause and typically develop coronary heart …
increase in the risk for this disease after menopause and typically develop coronary heart …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
[HTML][HTML] Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
[HTML][HTML] DNA methylation GrimAge strongly predicts lifespan and healthspan
AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
[HTML][HTML] DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
Menopause: a cardiometabolic transition
RE Nappi, P Chedraui, I Lambrinoudaki… - The Lancet Diabetes & …, 2022 - thelancet.com
Menopause is often a turning point for women's health worldwide. Increasing knowledge
from experimental data and clinical studies indicates that cardiometabolic changes can …
from experimental data and clinical studies indicates that cardiometabolic changes can …