Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …

Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of
bioactive lipids, including the proapoptotic compound ceramide and the proliferative …

We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:
1, 18: 0 sphingoid backbone, C 14-C 26 N-acyl part) of" normal" sphingolipid levels in …

Platelet microparticles (PMP) are endogenous substances generated during the coagulation
process in a hypercoagulable state. This study demonstrated that PMP promote the …

The concentration of sphingosine 1-phosphate (S1P) in plasma or serum is much higher
than the half-maximal concentration of the sphingolipid needed to stimulate its receptors …

Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific
receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly …