Mitochondria are dynamic organelles of endosymbiotic origin that are essential components
of eukaryal cells. They contain their own genetic machinery, have multicopy genomes and …

Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

MetaNetX/MNXref is a reconciliation of metabolites and biochemical reactions providing
cross-links between major public biochemistry and Genome-Scale Metabolic Network …

Chondrocytes are typically known for their anaerobic metabolism both in vivo and under
culture conditions in vitro. However, chondrocytes have been shown to display greater …

Purpose To understand the role of the mitochondrial oxodicarboxylate carrier (SLC25A21) in
the development of spinal muscular atrophy-like disease. Methods We identified a novel …

Immune cell− derived IL-17A is one of the key pathogenic cytokines in psoriasis, an
immunometabolic disorder. Although IL-17A is an established regulator of cutaneous …

Mitochondria are subcellular organelles present in almost all eukaryotic cells, which play a
central role in cellular metabolism. Different tissues, health and age conditions are …

Genome-scale models of metabolism (GEM) are used to study how metabolism varies in
different physiological conditions. However, the great number of reactions involved in GEM …

High-throughput technologies for genomics, transcriptomics, proteomics, and metabolomics,
and integrative analysis of these data, enable new, systems-level insights into disease …

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by a highly invasive
pannus formation consisting mainly of Synovial Fibroblasts (RASFs). This pannus leads to …