Muscle–organ crosstalk: the emerging roles of myokines

MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

Physical activity and muscle–brain crosstalk

BK Pedersen - Nature Reviews Endocrinology, 2019 - nature.com
Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Interleukin-6: designing specific therapeutics for a complex cytokine

C Garbers, S Heink, T Korn, S Rose-John - Nature reviews Drug …, 2018 - nature.com
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …

Interleukin-6 family cytokines

S Rose-John - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …

“Sweet death”: fructose as a metabolic toxin that targets the gut-liver axis

MA Febbraio, M Karin - Cell metabolism, 2021 - cell.com
Glucose and fructose are closely related simple sugars, but fructose has been associated
more closely with metabolic disease. Until the 1960s, the major dietary source of fructose …

[HTML][HTML] Origin and function of stress-induced IL-6 in murine models

H Qing, R Desrouleaux, K Israni-Winger, YS Mineur… - Cell, 2020 - cell.com
Acute psychological stress has long been known to decrease host fitness to inflammation in
a wide variety of diseases, but how this occurs is incompletely understood. Using mouse …

Macrophage cytokines: involvement in immunity and infectious diseases

G Arango Duque, A Descoteaux - Frontiers in immunology, 2014 - frontiersin.org
The evolution of macrophages has made them primordial for both development and
immunity. Their functions range from the shaping of body plans to the ingestion and …

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …