The molecular effects of acrolein
Acrolein is a highly electrophilic α, β-unsaturated aldehyde to which humans are exposed in
a variety of environmental situations, particularly as a component of smoke. In addition, as a …
a variety of environmental situations, particularly as a component of smoke. In addition, as a …
Fate and effects of acrolein
DP Ghilarducci, RS Tjeerdema - Reviews of Environmental Contamination …, 1995 - Springer
Acrolein, an α, β-unsaturated aldehyde, is a highly reactive, irritating chemical derived from
a variety of sources. It occurs as a product of organic pyrolysis, a metabolite of various …
a variety of sources. It occurs as a product of organic pyrolysis, a metabolite of various …
[图书][B] Reviews of environmental contamination and toxicology
DM Whitacre - 2008 - Springer
Exposure to arsenic-contaminated drinking water is a major threat to human health. Millions
of people across the world are exposed to arsenic-contaminated drinking water with …
of people across the world are exposed to arsenic-contaminated drinking water with …
Genotoxicity of lipid oxidation compounds
Lipid peroxidation, the oxidative degradation of membrane lipids by reactive oxygen species
generates a large variety of breakdown products such as alkanes, aldehydes, ketones …
generates a large variety of breakdown products such as alkanes, aldehydes, ketones …
Mutagenicity of acrolein and acrolein-induced DNA adducts
X Liu, M Zhu, J Xie - Toxicology mechanisms and methods, 2010 - Taylor & Francis
Acrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with
deoxyguanosine generates α-hydroxy-1, N2-propano-2′-deoxyguanosine (α-HOPdG) and …
deoxyguanosine generates α-hydroxy-1, N2-propano-2′-deoxyguanosine (α-HOPdG) and …
Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study
M Matsumoto, S Yamano, H Senoh, Y Umeda… - Regulatory Toxicology …, 2021 - Elsevier
The carcinogenicity and chronic toxicity of acrolein was examined by whole body inhalation
to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both sexes for two years …
to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both sexes for two years …
Reduced 293T Cell Susceptibility to Acrolein Due to Aldose Reductase–like-1 Protein Expression
X Zu, R Yan, S Robbins, PA Krishack… - Toxicological …, 2007 - academic.oup.com
Acrolein is a highly reactive α, β-unsaturated aldehyde produced endogenously during lipid
peroxidation and naturally distributed pervasively in living environments, posing serious …
peroxidation and naturally distributed pervasively in living environments, posing serious …
Acute effects of acrolein in human volunteers during controlled exposure
AM Dwivedi, G Johanson, JC Lorentzen… - Inhalation …, 2015 - Taylor & Francis
Context: Acrolein is a reactive aldehyde mainly formed by combustion. The critical effect is
considered to be irritation of the eyes and airways; however, the scarce data available make …
considered to be irritation of the eyes and airways; however, the scarce data available make …
Mutagenic/recombinogenic effects of four lipid peroxidation products in Drosophila
The human diet is an important factor in the development of different diseases. Lipid
peroxidation during frying in edible vegetable liquid oils of food components is a mechanism …
peroxidation during frying in edible vegetable liquid oils of food components is a mechanism …
Stereospecific Formation of the (R)-γ-Hydroxytrimethylene Interstrand N2-dG:N2-dG Cross-Link Arising from the γ-OH-1,N2-Propano-2′-deoxyguanosine …
H Huang, HY Kim, ID Kozekov, YJ Cho… - Journal of the …, 2009 - ACS Publications
Acrolein reacts with dG to form hydroxylated 1, N 2-propanodeoxyguanosine (OH-PdG)
adducts. Most abundant are the epimeric 3-(2-deoxy-β-d-erythro-pentofuranosyl)-5, 6, 7, 8 …
adducts. Most abundant are the epimeric 3-(2-deoxy-β-d-erythro-pentofuranosyl)-5, 6, 7, 8 …