The molecular effects of acrolein

JP Kehrer, SS Biswal - Toxicological Sciences, 2000 - academic.oup.com
Acrolein is a highly electrophilic α, β-unsaturated aldehyde to which humans are exposed in
a variety of environmental situations, particularly as a component of smoke. In addition, as a …

Fate and effects of acrolein

DP Ghilarducci, RS Tjeerdema - Reviews of Environmental Contamination …, 1995 - Springer
Acrolein, an α, β-unsaturated aldehyde, is a highly reactive, irritating chemical derived from
a variety of sources. It occurs as a product of organic pyrolysis, a metabolite of various …

[图书][B] Reviews of environmental contamination and toxicology

DM Whitacre - 2008 - Springer
Exposure to arsenic-contaminated drinking water is a major threat to human health. Millions
of people across the world are exposed to arsenic-contaminated drinking water with …

Genotoxicity of lipid oxidation compounds

PM Eckl, N Bresgen - Free radical biology and medicine, 2017 - Elsevier
Lipid peroxidation, the oxidative degradation of membrane lipids by reactive oxygen species
generates a large variety of breakdown products such as alkanes, aldehydes, ketones …

Mutagenicity of acrolein and acrolein-induced DNA adducts

X Liu, M Zhu, J Xie - Toxicology mechanisms and methods, 2010 - Taylor & Francis
Acrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with
deoxyguanosine generates α-hydroxy-1, N2-propano-2′-deoxyguanosine (α-HOPdG) and …

Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study

M Matsumoto, S Yamano, H Senoh, Y Umeda… - Regulatory Toxicology …, 2021 - Elsevier
The carcinogenicity and chronic toxicity of acrolein was examined by whole body inhalation
to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both sexes for two years …

Reduced 293T Cell Susceptibility to Acrolein Due to Aldose Reductase–like-1 Protein Expression

X Zu, R Yan, S Robbins, PA Krishack… - Toxicological …, 2007 - academic.oup.com
Acrolein is a highly reactive α, β-unsaturated aldehyde produced endogenously during lipid
peroxidation and naturally distributed pervasively in living environments, posing serious …

Acute effects of acrolein in human volunteers during controlled exposure

AM Dwivedi, G Johanson, JC Lorentzen… - Inhalation …, 2015 - Taylor & Francis
Context: Acrolein is a reactive aldehyde mainly formed by combustion. The critical effect is
considered to be irritation of the eyes and airways; however, the scarce data available make …

Mutagenic/recombinogenic effects of four lipid peroxidation products in Drosophila

E Demir, F Turna, B Kaya, A Creus, R Marcos - Food and chemical …, 2013 - Elsevier
The human diet is an important factor in the development of different diseases. Lipid
peroxidation during frying in edible vegetable liquid oils of food components is a mechanism …

Stereospecific Formation of the (R)-γ-Hydroxytrimethylene Interstrand N2-dG:N2-dG Cross-Link Arising from the γ-OH-1,N2-Propano-2′-deoxyguanosine …

H Huang, HY Kim, ID Kozekov, YJ Cho… - Journal of the …, 2009 - ACS Publications
Acrolein reacts with dG to form hydroxylated 1, N 2-propanodeoxyguanosine (OH-PdG)
adducts. Most abundant are the epimeric 3-(2-deoxy-β-d-erythro-pentofuranosyl)-5, 6, 7, 8 …