Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Injectable biomimetic hydrogels have great potential for use in regenerative medicine as
cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Using rational design, an engineered myoglobin‐based catalyst capable of catalyzing the
cyclopropanation of aryl‐substituted olefins with catalytic proficiency (up to 46 800 …

Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced,
azide-bound, and carbon monoxide–bound states were determined at 2.30, 2.35, 2.9, and …

The structural elements which afford molecular recognition and discrimination events in
macromol-ecule-ligand interactions dictate the basis of protein function. Nature has evolved …

Nitric oxide (NO) has been implicated as mediator in a variety of physiological functions,
including neurotransmission, platelet aggregation, macrophage function, and vasodilation …

We have used x-ray crystallography to determine the structures of sperm whale myoglobin
(Mb) in four different ligation states (unligated, ferric aquomet, oxygenated, and …

The FixL proteins are biological oxygen sensors that restrict the expression of specific genes
to hypoxic conditions. FixL's oxygen-detecting domain is a heme binding region that controls …