CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

[HTML][HTML] Role of phytohormones in regulating cold stress tolerance: physiological and molecular approaches for developing cold-smart crop plants

A Raza, S Charagh, S Najafi-Kakavand, S Abbas… - Plant Stress, 2023 - Elsevier
Global climate variations induce extreme temperatures and significantly decrease crop
production, leading to food insecurity worldwide. Temperature extremes (mainly cold stress …

Genetically modified crops: current status and future prospects

K Kumar, G Gambhir, A Dass, AK Tripathi, A Singh… - Planta, 2020 - Springer
Main conclusion While transgenic technology has heralded a new era in crop improvement,
several concerns have precluded their widespread acceptance. Alternative technologies …

Jasmonic acid: a key frontier in conferring abiotic stress tolerance in plants

A Raza, S Charagh, Z Zahid, MS Mubarik, R Javed… - Plant Cell Reports, 2021 - Springer
Abiotic stresses are the primary sources of crop losses globally. The identification of key
mechanisms deployed and established by plants in response to abiotic stresses is …

[HTML][HTML] Construct design for CRISPR/Cas-based genome editing in plants

MM Hassan, Y Zhang, G Yuan, K De, JG Chen… - Trends in Plant …, 2021 - cell.com
CRISPR construct design is a key step in the practice of genome editing, which includes
identification of appropriate Cas proteins, design and selection of guide RNAs (gRNAs), and …

Next-generation breeding strategies for climate-ready crops

A Razzaq, P Kaur, N Akhter, SH Wani… - Frontiers in Plant …, 2021 - frontiersin.org
Climate change is a threat to global food security due to the reduction of crop productivity
around the globe. Food security is a matter of concern for stakeholders and policymakers as …

A manipulative interplay between positive and negative regulators of phytohormones: A way forward for improving drought tolerance in plants

MS Mubarik, SH Khan, M Sajjad, A Raza… - Physiologia …, 2021 - Wiley Online Library
Among different abiotic stresses, drought stress is the leading cause of impaired plant
growth and low productivity worldwide. It is therefore essential to understand the process of …

CRISPR-mediated engineering across the central dogma in plant biology for basic research and crop improvement

D Pramanik, RM Shelake, MJ Kim, JY Kim - Molecular Plant, 2021 - cell.com
The central dogma (CD) of molecular biology is the transfer of genetic information from DNA
to RNA to protein. Major CD processes governing genetic flow include the cell cycle, DNA …

Gene-by-environment interactions in plants: Molecular mechanisms, environmental drivers, and adaptive plasticity

JD Napier, RW Heckman, TE Juenger - The Plant Cell, 2023 - academic.oup.com
Plants demonstrate a broad range of responses to environmental shifts. One of the most
remarkable responses is plasticity, which is the ability of a single plant genotype to produce …

DNA cytosine methylation dynamics and functional roles in horticultural crops

P Liu, R Liu, Y Xu, C Zhang, Q Niu… - Horticulture Research, 2023 - academic.oup.com
Methylation of cytosine is a conserved epigenetic modification that maintains the dynamic
balance of methylation in plants under the regulation of methyltransferases and …