Objective To investigate the association between the risk of nonsyndromic cleft lip with or
without cleft palate (NSCL/P) and the IRF6 rs2235371 (C> T) polymorphism in Chinese Han …

Van der Woude syndrome (VWS) is an autosomal dominant malformation syndrome
characterized by orofacial clefting (OFC) and lower lip pits. The clinical presentation of VWS …

Human facial morphology is a combination of many complex traits. Little is known about the
genetic basis of common facial morphological variation. Existing association studies have …

Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact. Since
tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four …

Non-syndromic oral clefts share the main clinical features of Van der Woude Syndrome
(VWS), with the exception of the lower lip pit. Thus, about 15% of VWS cases are …

Abstract Objectives/Hypothesis: Orofacial clefts are the most common craniofacial birth
defects in humans, with the majority of orofacial clefts occurring as nonsyndromic cleft lip …

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common
craniofacial malformation in humans. Three polymorphisms, rs2235371 and rs642961 in …

Introduction Transcription factors are very diverse family of proteins involved in activating or
repressing the transcription of a gene at a given time. Several studies using animal models …

Objective Subjects with cleft lip and palate (CLP) present high prevalence of dental
agenesis. Among candidate genes for these phenotypes is IRF6. However, genetic studies …

Objectives Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common birth
defect which is strongly associated with genetic factors. Previous studies in several …