Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells

RA Kore, JL Edmondson, SV Jenkins… - … and biophysics reports, 2018 - Elsevier
Hypoxia, a hallmark characteristic of glioblastoma (GBM) induces changes in the
transcriptome and the proteome of tumor cells. We discovered that hypoxic stress produces …

Berberine ameliorates high glucose-induced cardiomyocyte injury via AMPK signaling activation to stimulate mitochondrial biogenesis and restore autophagic flux

W Hang, B He, J Chen, L Xia, B Wen, T Liang… - Frontiers in …, 2018 - frontiersin.org
Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to
the impairment of mitochondrial function. Berberine has been shown to be a promising effect …

Pegylated bis-indolyl polyurethane dendrimer: Empty drug carrier with prominent anticancer activity

I Bargathulla, BA Ashwaq, S Sathiyaraj… - European Polymer …, 2021 - Elsevier
Blocked isocyanate-terminated, bioactive bis-indole based polyurethane dendrimers of
generation G0–G3 were subjected to urethane interchange reaction with poly (ethylene …

shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation

Z Meng, MY Song, CF Li, JQ Zhao - Biochemical and biophysical research …, 2017 - Elsevier
Myocardial ischemia-reperfusion (I/R) injury always occur during the recovery of myocardial
blood supply with high morbidity and mortality. Although, various therapeutic schedules …

Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling

G Nagaraj, E Vellaichamy - Endocrine, 2024 - Springer
Introduction Natriuretic peptide receptor-A (NPR-A) signaling system is considered as an
intrinsic productive mechanism of the heart that opposes abnormal cardiac remodeling and …

Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts

T Thottakara, A Padmanabhan, T Tanriverdi… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is associated with phenotypic variability. To gain
insights into transcriptional regulation of cardiac phenotype, single-nucleus linked RNA …

[PDF][PDF] BNP 信号通路在眶下神经损伤大鼠模型中的研究

张越, 姚育智, 朱大卫, 王烈成, 王元银 - 安徽医科大学学报, 2018 - aydxb.cn
摘要目的通过构建大鼠三叉神经痛动物模型, 探究眶下神经慢性压迫对大鼠三叉神经节内BNP
受体NPR-A 表达及cGMP 含量的影响. 方法通过大鼠眶下神经慢性压迫损伤构建三叉神经痛 …

[引用][C] Anti-Hypertrophic Npr1 Gene Transcription in Triiodo-L-Thyronine (T3) Treated H9c2 Cells: Involvement of β-Adrenergic Signalling

G Nagaraj, J Bheeman, S Jawahar, DM Nachiappan