Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …

Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in
recent years and has a poor prognosis. Pyroptosis is regulated via the activation of …

Background Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1), which
displays a distinct long noncoding RNA (lncRNA) expression profile, has been defined as a …

Background Super enhancers (SE) play pivotal roles in cell identity and diseases occur
including tumorigenesis. The depletion of SE‐associated lncRNA transcripts, also known as …

Genome-wide analyses have revealed that long noncoding RNAs (lncRNAs) are not only
passive transcription products, but also major regulators of genome structure and …

Every year there is more and more evidence that non-coding RNAs play an important role in
biological processes affecting various levels of organization of living systems: from the …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that
arises from the oncogenic transformation of developing T cells during T-lymphopoiesis …

As key developmental regulators, HOX cluster genes have varied and context-specific roles
in normal and malignant hematopoiesis. A complex interaction of transcription factors …

The noncoding genome presents a largely untapped source of new biological insights,
including thousands of long noncoding RNA (lncRNA) loci. While lncRNA dysregulation has …