A decade of GWAS results in lung cancer

Y Bossé, CI Amos - Cancer Epidemiology, Biomarkers & Prevention, 2018 - AACR
Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

Epidemiology of lung cancer

AG Schwartz, ML Cote - Lung cancer and personalized medicine: Current …, 2016 - Springer
Lung cancer continues to be one of the most common causes of cancer death despite
understanding the major cause of the disease: cigarette smoking. Smoking increases lung …

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Z Huang, S Sun, M Lee, AY Maslov, M Shi… - Nature …, 2022 - nature.com
Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …

Exploring and visualizing large-scale genetic associations by using PheWeb

SA Gagliano Taliun, P VandeHaar, AP Boughton… - Nature …, 2020 - nature.com
To the Editor—Advances in genotyping and sequencing technologies, the growing
availability of electronic health records for research use and the emergence of population …

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Y Wang, JD McKay, T Rafnar, Z Wang, MN Timofeeva… - Nature …, 2014 - nature.com
We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …

Lung cancer in China: challenges and interventions

J She, P Yang, Q Hong, C Bai - Chest, 2013 - Elsevier
In 2008, lung cancer replaced liver cancer as the number one cause of death among people
with malignant tumors in China. The registered lung cancer mortality rate increased by …

[HTML][HTML] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

MT Landi, N Chatterjee, K Yu, LR Goldin… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

MS Artigas, DW Loth, LV Wain, SA Gharib, M Obeidat… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12. 12 and 22q12. 2 in Han Chinese

Z Hu, C Wu, Y Shi, H Guo, X Zhao, Z Yin, L Yang… - Nature …, 2011 - nature.com
Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic
factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a …

Molecular biology of lung cancer: clinical implications

JE Larsen, JD Minna - Clinics in chest medicine, 2011 - chestmed.theclinics.com
Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …