Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

This paper takes a comprehensive look at the latest evidence regarding the significance of
the first 1000 days, and the biological, global, environmental and social factors that influence …

Early-life adversity increases the risk for psychopathology in later life. The underlying
mechanism (s) is unknown, but epigenetic variation represents a plausible candidate. Early …

Prenatal maternal psychological distress increases risk for adverse infant outcomes.
However, the biological mechanisms underlying this association remain unclear. Prenatal …

Recent studies demonstrate that exposure to stress changes the composition of the
intestinal microbiota, which is associated with development of stress-induced changes to …

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

Puberty presents remarkable individual differences in timing reaching over 5 years in
humans. We put emphasis on the two edges of the age distribution of pubertal signs in …

Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …