Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Abstract Background Ovarian cancer (OvCa) is one of the most common malignant diseases
of the female reproductive system in the world. The majority of OvCa is diagnosed with …

Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination.
Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight …

Multiple myeloma (MM) is a plasma cell tumor marked by clonal evolution and preceded by
a premalignant stage, which progresses via molecular pathway deregulation, including MYC …

Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the
bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is …

RNA-binding proteins (RBPs) play an important role in RNA metabolism, regulating the
stability, localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network …

The immunocheckpoint protein PD-1/PD-L1 is considered a promising target for cancer
immunotherapeutics. However, the objective response rate using antibodies that block the …

Metastasis and resistance to therapy significantly contribute to cancer-related deaths.
Growing body of evidence suggest that altered expression of microRNAs (miRNAs) is one of …