Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

The Filoviridae are a family of negative-strand RNA viruses that include several important
human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which …

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV)
detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and …

Here, we show that the US Food and Drug Administration-approved oral drug nitazoxanide
(NTZ) broadly amplifies the host innate immune response to viruses and inhibits Ebola virus …

Double-stranded RNA (dsRNA) is synthesized during the course of infection by RNA viruses
as a byproduct of replication and transcription and acts as a potent trigger of the host innate …

Suppression of innate immune responses during filoviral infection contributes to disease
severity. Ebola (EBOV) and Marburg (MARV) viruses each encode a VP35 protein that …

Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by
blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and …

Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus,
causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While …

Highlights•Host proteins must distinguish viral RNA from self RNA to trigger immune
responses.•5′ RNA cap is key specificity determinant of host signaling.•Viruses use a …

Cytosolic sensing of pathogens is essential to a productive immune response. Recent
reports have emphasized the importance of signaling platforms emanating from organelles …