The termination of chemical neurotransmission in the central nervous system (CNS) involves
the rapid removal of neurotransmitter from synapses. This is fulfilled by specific transport …

▪ Abstract The cell body has classically been considered the exclusive source of axonal
proteins. However, significant evidence has accumulated recently to support the view that …

In the mammalian olfactory system, information from-1000 different odorant receptor types is
organized in the nose into four spatial zones. Each zone is a mosaic of randomly distributed …

Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-
3), are able to produce a long-lasting enhancement of synaptic transmission in the …

The proteins needed for growth and maintenance of the axon are generally believed to be
synthesized in the cell bodies and delivered to the axons by anterograde transport …

A growing body of metabolic and molecular evidence of an endogenous protein-
synthesizing machinery in the mature axon is a challenge to the prevailing dogma that the …

This article focuses on local protein synthesis as a basis for maintaining axoplasmic mass,
and expression of plasticity in axons and terminals. Recent evidence of discrete ribosomal …

The presence of a local mRNA translation system in axons and terminals was proposed
almost 40 years ago. Over the ensuing period, an impressive body of evidence has grown to …

Many axons carry out the synthesis of macromolecules independent of their cell bodies but
the nature, organization and magnitude of axonal protein synthesis remain unclear. We …

In neurons, the establishment and maintenance of distinct somatic, dendritic, and axonal
domains has long been known to rely on regulated traffic of organelles and proteins. More …