NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …
including environmental sensitivity, high reactivity toward amines and biothiols (including …
Smart self‐assembled hybrid hydrogel biomaterials
Hybrid biomaterials are systems created from components of at least two distinct classes of
molecules, for example, synthetic macromolecules and proteins or peptide domains. The …
molecules, for example, synthetic macromolecules and proteins or peptide domains. The …
Chemical protein synthesis: advances, challenges, and outlooks
Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …
decades, which has enabled chemists to reach the landscape of synthetic …
[HTML][HTML] Diversity of phage-displayed libraries of peptides during panning and amplification
The amplification of phage-displayed libraries is an essential step in the selection of ligands
from these libraries. The amplification of libraries, however, decreases their diversity and …
from these libraries. The amplification of libraries, however, decreases their diversity and …
[HTML][HTML] Peptide phage display as a tool for drug discovery: targeting membrane receptors
P Molek, B Strukelj, T Bratkovic - Molecules, 2011 - mdpi.com
Ligands selected from phage-displayed random peptide libraries tend to be directed to
biologically relevant sites on the surface of the target protein. Consequently, peptides …
biologically relevant sites on the surface of the target protein. Consequently, peptides …
Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes
Conspectus Chemical manipulation of naturally occurring peptides offers a convenient route
for generating analogs to screen against different therapeutic targets. However, the limited …
for generating analogs to screen against different therapeutic targets. However, the limited …
The thioredoxin system: a promising target for cancer drug development
The thioredoxin system is highly conserved system found in all living cells and comprises
NADPH, thioredoxin, and thioredoxin reductase. This system plays a critical role in …
NADPH, thioredoxin, and thioredoxin reductase. This system plays a critical role in …
Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention
JM Mason - Future medicinal chemistry, 2010 - Taylor & Francis
The concept of peptides as therapeutic agents has been historically disregarded by the
pharmaceutical industry on account of their susceptibility to degradation, their size and …
pharmaceutical industry on account of their susceptibility to degradation, their size and …
[HTML][HTML] Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo
B Kass, S Schemmert, C Zafiu, M Pils, O Bannach… - Cell Reports …, 2022 - cell.com
The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug
development of Alzheimer's disease (AD). AD mouse models that develop Aβ pathology …
development of Alzheimer's disease (AD). AD mouse models that develop Aβ pathology …
Novel protein science enabled by total chemical synthesis
SBH Kent - Protein Science, 2019 - Wiley Online Library
Chemical synthesis is a well‐established method for the preparation in the research
laboratory of multiple‐tens‐of‐milligram amounts of correctly folded, high purity protein …
laboratory of multiple‐tens‐of‐milligram amounts of correctly folded, high purity protein …