Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer's disease, Parkinson's disease, and long-COVID through NRF2 activation to counteract …

T Satoh, D Trudler, CK Oh, SA Lipton - Antioxidants, 2022 - mdpi.com
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …

[HTML][HTML] Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe?

M López-Moreno, M Garcés-Rimón, M Miguel - Journal of Functional …, 2022 - Elsevier
The intake of foods derived from plants has been proposed as an useful strategy in the
prevention of several chronic diseases. However, plants also possess a group of substances …

[HTML][HTML] Mitochondria: It is all about energy

A Casanova, A Wevers, S Navarro-Ledesma… - Frontiers in …, 2023 - frontiersin.org
Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

SARS-CoV-2 infection and oral health: therapeutic opportunities and challenges

CJ Coke, B Davison, N Fields, J Fletcher… - Journal of Clinical …, 2021 - mdpi.com
The novel corona virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2),
and the disease it causes, COVID-19 (Coronavirus Disease-2019) have had multi-faceted …

Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications

M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …

Role of NRF2 and Sirtuin activators in COVID-19

H Khan, S Patel, A Majumdar - Clinical Immunology, 2021 - Elsevier
COVID-19 is a pandemic requiring immediate solution for treatment because of its complex
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …

[HTML][HTML] Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

Kimchi intake alleviates obesity-induced neuroinflammation by modulating the gut-brain axis

N Kim, J Lee, HS Song, YJ Oh, MS Kwon, M Yun… - Food Research …, 2022 - Elsevier
A high-fat diet (HFD) induces low-grade, chronic inflammation throughout the body including
the hypothalamus, a key brain region involved in the control of satiety and energy …

Anti-inflammatory and anticancer properties of birch bark-derived betulin: Recent developments

HS Tuli, K Sak, DS Gupta, G Kaur, D Aggarwal… - Plants, 2021 - mdpi.com
Birch tree bark-derived betulin has attracted scientific interest already for several centuries,
being one of the first natural products identified from plants. However, the cellular events …