Tissue repair is a very complex event and involves a continuously orchestrated sequence of
signals and responses from platelets, fibroblasts, epithelial, endothelial and immune cells …

The role of Pannexin (PANX) channels during collective and single cell migration is
increasingly recognized. Amongst many functions that are relevant to cell migration, here we …

The skin is a highly organized tissue composed of multiple layers and cell types that require
coordinated cell to cell communication to maintain tissue homeostasis. In skin cancer, this …

Pannexins are single-membrane large-pore channels that release ions and ATP upon
activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ …

Abstract Pannexin 3 (PANX3) is a member of the pannexin family of single membrane
channel-forming glycoproteins. Originally thought to have a limited localization in cartilage …

Objective Osteoarthritis (OA) results in pathologic changes in the joint tissue. The
mechanisms driving disease progression remain largely unclear, and thus disease …

Abstract Pannexin 3 (Panx3), a member of the gap junction pannexin family is required for
the development of hard tissues including bone, cartilage and teeth. However, the role of …

Abstract Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a
wide variety of tissues including the skin, bone, and cochlea. To date, the use of single …

Wound healing is a dynamic process required to maintain skin integrity and which relies on
the precise migration of different cell types. A key molecule that regulates this process is …

The development of mammalian adaptive (ie, B and T cell-mediated) immune responses is
tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from …