Despite advances in high-throughput sequencing that have revolutionized the discovery of
gene defects in rare Mendelian diseases, there are still gaps in translating individual …

Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

The relative proportion of additive and non-additive variation for complex traits is important
in evolutionary biology, medicine, and agriculture. We address a long-standing controversy …

Increasing wheat yield is a key global challenge to producing sufficient food for a growing
human population. Wheat grain yield can be boosted by exploiting heterosis, the superior …

Classical quantitative genetic analyses estimate additive and non-additive genetic and
environmental components of variance from phenotypes of related individuals without …

A recombinant inbred line (RIL) population was evaluated in seven field experiments
representing four environments: water stress at flowering (WS) and well-watered (WW) …

It has long been recognized that epistasis or interactions between non-allelic genes plays
an important role in the genetic control and evolution of quantitative traits. However, the …

Genomic prediction methods based on multiple markers have potential to include
nonadditive effects in prediction and analysis of complex traits. However, most …

Interaction between genes, or epistasis, is found to be common and it is a key concept for
understanding adaptation and evolution of natural populations, response to selection in …

Background Obesity has been shown to increase breast cancer risk. FTO is a novel gene
which has been identified through genome wide association studies (GWAS) to be related to …