Heart failure is one of the leading causes of mortality in the western world and encompasses
a wide spectrum of cardiac pathologies. When the heart experiences extended periods of …

Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Several peptides play an important role in physiological and pathological conditions into the
cardiovascular system. In addition to well-known vasoactive agents such as angiotensin II …

Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R)
injuries. However, little is known about its role in the regulation of intracellular Ca2+ …

The urocortins (Ucns), endogenous peptides belonging to the corticotropin-releasing factor
(CRF) family, are increasingly recognized as having diverse and important multi-system …

Insulin resistance (IR) in skeletal muscle is an important component of both type 2 diabetes
and the syndrome of sarcopaenic obesity, for which there are no effective therapies …

The urocortins are members of the corticotropin releasing hormone (CRH) family of peptide
hormones. The archetypal member of this family, CRH, plays an important role in regulating …

Urocortins (Ucn) 1, 2 and 3 are a group of endogenous peptide hormones belonging to the
corticotropin-releasing hormone (CRH) family of peptides. The presence of urocortins has …

Nuclear factor, erythroid 2 like 2 (Nfe2l2 or Nrf2), is a transcription factor that protects cells by
maintaining a homeostatic redox state during stress. The constitutive expression of Nrf2 …

Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are orphan
receptors involved in regulation of neurogenesis and organogenesis. COUP-TF family …