The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Genome-wide transcriptional profiling of human epithelial cells revealed that repression of Id
inhibitors of differentiation (Id1, Id2, and Id3) is a general feature of the TGFβ cytostatic …

Id proteins are important parts of signaling pathways involved in development, cell cycle and
tumorigenesis. They were first shown to act as dominant negative antagonists of the basic …

There is increasing evidence that some cancers are hierarchically organized, sustained by a
relatively rare population of cancer-initiating cells (C-ICs). Although the capacity to initiate …

Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in
regulating a variety of cellular processes, including cellular growth, senescence …

MiR-125a has been characterized as a tumor suppressor in several cancers. However, the
role of miR-125a in cervical cancer is unknown. In this study, we found the expression of …

Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and
progression of many cancer types, including leukemia. However, the ID1 protein has not yet …

A large body of evidence has been accumulated that demonstrates dominant effects of Id
proteins on different aspects of cellular growth. Generally, constitutive expression of Id not …

The inhibitor of DNA binding (Id) proteins are regulators of cell cycle and cell differentiation.
Of all Id family proteins, Id1 is mostly linked to tumorigenesis, cellular senescence as well as …